Millipore Corporation”s ChromaSorb membrane absorber binds negative impurities from host cell protein (HCP), DNA, endotoxins, and viruses at salt concentrations well above those of traditional resins and membranes. The solution enables these devices to function at a wide range of salt concentrations, eliminating the need to dilute feedstreams prior to processing. This helps avoid the downstream bottleneck of buffer tank capacity that is typical of disposable adsorbers at the polishing step. The ChromaSorb 0.08 mL process development device requires a third less volume of feedstock than other membrane adsorbers. ChromaSorb 0.08 mL devices for process development, optimization and scale up are currently available; ChromaSorb 50 mL and 500 mL devices will be available soon.
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